What if one of the keys to our mental and physical well-being lay in the little fat bubbles that travel through our brains?
After more than 30 years of mystery, science has finally understood how endocannabinoids - the natural molecules inspired by cannabis - circulate in our nervous system. A fascinating discovery with major therapeutic implications.

1️⃣ Endocannabinoids: a mysterious system at the heart of our brain

The human body produces its own "cannabinoids", known as endocannabinoids. Among them,anandamide and 2-AG play a crucial role in pain management, anxiety regulation, memory and sleep.

But until now, we had no idea how these molecules moved from one neuron to another.
Unlike serotonin or dopamine, these molecules are lipophilic: they don't like water, which made it virtually impossible to observe them using conventional microscopy tools.

The result? Three decades of scientific limbo.

2️⃣ The revelation: lipid vesicles as brain cabs

Using a new-generation fluorescent sensor technology, a team of researchers at Leiden University (Netherlands) has captured the movement of 2-AG in the brain in real time.

🧪 What they discovered is fascinating: 2-AG is transported inside fat microvesicles, veritable little biological vehicles.
Each vesicle contains around 2,000 molecules of 2-AG.

Better still: if we block the formation of these vesicles, the concentration of 2-AG falls. And if we prevent 2-AG production, the vesicles are empty.
💡 Irrefutable proof of this mechanism.

3️⃣ Why is this a major discovery?

Because it completely redefines our understanding of neuronal signaling, and especially of the endocannabinoid system, the pillar of inner equilibrium (or homeostasis).

But it's not just scientific progress. It's also a potential medical breakthrough:

• If we understand how 2-AG moves, we can imagine targeted therapies to increase or reduce its effect.
• This opens the way to new treatments for chronic pain, neurological disorders and epilepsy.
• And it could even make it possible to better administer CBD or therapeutic THC, by mimicking these natural mechanisms.

As Professor Van der Stelt, head of the study, points out:

"We may be looking at a whole new form of brain communication.

4️⃣ Science in motion... and full of promise

Behind this breakthrough lies a broader intuition: other lipid messengers in the brain could use the same transport system.
In other words, what was thought to be specific to endocannabinoids could be just the tip of the iceberg.

If confirmed, this would represent a revolution in our understanding of the human brain... and in the therapeutic strategies of the future.

📢 And what do you think of this discovery?

Is this the beginning of a new era for CBD research and brain medicine?
💬 Share your reactions in comments, and send this article to your loved ones who are passionate about neuroscience or curious about the effects of cannabis on the human body.